Solid dispersion is one of the vastly accepted and practically economical processes in bioavailability enhancement study. The present investigation deals mostly with increase in solubility and dissolution rate of BCS class 4 drugs for enhancement of oral bioavailability. For the same solid dispersion were p repared and analyzed for appropriate concentration of drug polymer ratio by phase solubility analysis. The solvent evaporation study widely accepted due to its efficient solid dispersion in lesser efforts. The study designs were prepared with specific concentration of drug and polymer ratio with the help of high throughput model i.e. Central Composite Design (by Design Expert trial copy) by specific design of experiment with full factorial design (DOE). The fixed variables were concentration of polymers and dependant variables were dissolution and permeability across bio-membrane in in-vitro model.
Bcs Class 4 Dissolution
![Bcs Class 4 Bcs Class 4](https://image.slidesharecdn.com/bcsclassificationsystem-121210120413-phpapp01/95/bcs-classification-system-22-638.jpg?cb=1355141266)
BCS Class IV drugs: Highly notorious candidates for formulation development Article (PDF Available) in Journal of Controlled Release 248 January 2017 with 8,056 Reads DOI: 10.1016/j.jconrel.
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The prepared dispersion investigated for dissolution and permeability improvement using USP Type II apparatus and modified everted gut sac model which leads to improvement of quality of whole formulation with Quality by design efficiently. BCS class 4 drugs used for present study are Cefuroxime Axetil, Cefpodoxime Proxetil, Furosemide. Cefuroxime Axetil is the second generation Beta Lactam antibiotic is acted with binding to specific penicillin-binding proteins which are generally located inside the bacterial cell wall. T he proteins generally inhibit the bacterial cell wall synthesis and causes cell lysis by interfering with an autolysin inhibitor. Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class.
Bcs Class 1 Drugs
Dragon age inquisition pc free. It inhibits bacterial cell wall synthesis by interfering by its ability of covalently binding to the penicillin-binding proteins. Furosemide inhibits primarily the reabsorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle these drugs are selected as they include in BCS class 4 drugs. The DOE with full factorial design is widely used for optimization of pharmaceutical dosage formulation process and excipients concentration depends upon response surface plot of individual polymer responsibility in optimized result. DOE is systematic tool for increasing efficiency development of pharmaceutical dosage forms and helps in improvement of research and development work.